SCUBE2

Across TCGA pan-cancer cohorts, SCUBE2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SCUBE2 data layer compared with 28 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SCUBE2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SCUBE2 expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

PDAC, GBM, and HNSC are the cancer types where SCUBE2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.592	0.357	.009	23	view →
GBM	OS	Tertile	All	0.819	0.267	.006	8	view →
HNSC	DFS	Quartile	IV	1.000	0.324	.038	8	view →
LSCC	DFS	Tertile	All	0.336	0.982	.010	6	view →
LUAD	DFS	Tertile	III,IV	0.380	0.916	.008	6	view →
UCEC	OS	Median	II,III,IV	0.675	1.000	.030	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SCUBE2–PDAC (DFS)

Open the PDAC breakdown →