SCTR

Across TCGA cell cohorts, SCTR mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCTR-associated genes across cancer lineages are DYDC1, GALP, and MS4A4A. Each is linked with SCTR in more than 1 cancer types. Because this analysis shows association rather than direction, both SCTR-to-partner and partner-to-SCTR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DYDC1 grouped by SCTR-low versus SCTR-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCTR→partner) and Y-score (partner→SCTR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DYDC1 →	+0.073	+5.087	<.001	.004	3	1
URINARY_TRACT	GALP →	+0.036	+5.087	<.001	.004	3	1
LARGE_INTESTINE	MS4A4A →	+0.176	+3.000	<.001	.006	3	1
LARGE_INTESTINE	CDX4 →	+0.007	+3.217	.001	.006	3	1
LARGE_INTESTINE	NAA11 →	+0.434	+3.443	<.001	.009	3	1
LARGE_INTESTINE	TAFA1 →	+0.236	+4.009	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

DYDC1 by SCTR expression — URINARY_TRACT

Explore this box plot interactively →