SCT

Across TCGA patient cohorts, SCT mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. COAD shows the largest number of these associations.

The most reproducible SCT-associated genes across cancer lineages are USP9YP2, RNU6-1309P, and RNU6-1187P. Each is linked with SCT in more than 1 cancer types. Because this analysis shows association rather than direction, both SCT-to-partner and partner-to-SCT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP9YP2 grouped by SCT-low versus SCT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCT→partner) and Y-score (partner→SCT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	USP9YP2 →	+0.054	+8.066	<.001	.007	3	1
COAD	RNU6-1309P →	+0.604	+5.357	<.001	.006	3	1
COAD	RNU6-1187P →	+0.832	+5.080	<.001	.008	3	1
COAD	RNU6-1250P →	+0.477	+5.693	<.001	.003	3	1
COAD	HTATSF1P1 →	+0.065	+5.893	<.001	.002	3	1
COAD	UBE2V1P16 →	+0.252	+7.409	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

USP9YP2 by SCT expression — UCEC

Explore this box plot interactively →