SCRT1

Across TCGA patient cohorts, SCRT1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCRT1-associated genes across cancer lineages are ATM, eIF4E, and Notch1. Each is linked with SCRT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCRT1-to-partner and partner-to-SCRT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SCRT1-low versus SCRT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCRT1→partner) and Y-score (partner→SCRT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.545	-2.584	.009	.011	3	2
UCEC	eIF4E →	+0.220	+3.000	.025	.036	3	1
UCEC	Notch1 →	+0.211	+3.013	.001	.018	3	1
UCEC	p62 Lck ligand →	+0.437	+3.009	.003	.019	3	1
UCEC	PDCD4 →	-0.714	-2.584	.001	.011	3	1
UCEC	Shc_pY317 →	-0.196	-3.169	.005	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

ATM by SCRT1 expression — UCEC

Explore this box plot interactively →