SCRT1

Across TCGA cell cohorts, SCRT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,338 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SCRT1-associated GO terms across cancer lineages are Regulation of mRNA splicing, via spliceosome, Regulation of protein localization to nucleus, and Positive regulation of double-strand break repair. Each is linked with SCRT1 in more than 6 cancer types. Because this analysis shows association rather than direction, both SCRT1-to-partner and partner-to-SCRT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mRNA splicing, via spliceosome grouped by SCRT1-low versus SCRT1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCRT1→partner) and Y-score (partner→SCRT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of mRNA splicing, via spliceosome →	+0.071	+0.028	<.001	<.001	3	7
LUNG_SCLC	Regulation of protein localization to nucleus →	+0.078	+1.431	<.001	.002	3	7
SOFT_TISSUE	Positive regulation of double-strand break repair →	+0.042	+0.041	.007	.007	3	6
UPPER_AERODIGESTIVE_TRACT	Zinc ion import into organelle →	-0.134	-0.036	.003	.007	3	5
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.142	+0.031	.002	.005	3	5
UPPER_AERODIGESTIVE_TRACT	Early endosome to late endosome transport →	+0.068	+0.036	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,338 associations by consensus.

Regulation of mRNA splicing, via spliceosome by SCRT1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →