SCRN1

Across TCGA patient cohorts, SCRN1 mutation is significantly associated with the RNA expression of many other genes, with 2,157 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCRN1-associated genes across cancer lineages are MIR7-3, SOSTDC1, and RGS1. Each is linked with SCRN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCRN1-to-partner and partner-to-SCRN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR7-3 grouped by SCRN1-low versus SCRN1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCRN1→partner) and Y-score (partner→SCRN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR7-3 →	+0.218	+4.757	<.001	.004	3	2
UCEC	SOSTDC1 →	-0.781	-2.239	.006	.001	3	2
UCEC	RGS1 →	+0.635	+2.354	.008	.003	3	2
UCEC	CBARP →	+0.629	+2.269	<.001	<.001	3	2
UCEC	HCN2 →	+0.347	+1.410	.005	.005	3	2
BRCA	CGB1 →	+0.039	+8.471	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,157 associations by consensus.

MIR7-3 by SCRN1 expression — CESC

Explore this box plot interactively →