SCRIB

Across TCGA pan-cancer cohorts, SCRIB Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SCRIB data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher SCRIB Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SCRIB expression acts as an unfavorable survival marker.

SCLC, PAAD, and UCEC are the cancer types where SCRIB Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	II,III,IV	0.082	0.702	<.001	33	view →
PAAD	DFS	Median	All	0.074	0.510	<.001	15	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
PRAD	DFS	Median	All	0.151	0.888	<.001	6	view →
COAD	DFS	Median	All	0.212	0.696	.034	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SCRIB–SCLC (OS)

Open the SCLC breakdown →