SCRIB

Across TCGA pan-cancer cohorts, SCRIB mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SCRIB data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SCRIB mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SCRIB expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, PDAC, and UCEC are the cancer types where SCRIB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.846	0.576	.001	21	view →
PDAC	OS	Tertile	III,IV	0.968	0.271	.002	14	view →
UCEC	DFS	Tertile	II,III,IV	1.000	0.494	.009	12	view →
LUAD	OS	Median	III,IV	0.775	0.221	.003	11	view →
CCRCC	OS	Median	IV	0.150	0.785	.040	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SCRIB–LSCC (DFS)

Open the LSCC breakdown →