SCRIB

Across TCGA patient cohorts, SCRIB protein abundance is significantly associated with the RNA expression of many other genes, with 12,012 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SCRIB-associated genes across cancer lineages are ZNF623, LRRC14, and TIGD5. Each is linked with SCRIB in more than 9 cancer types. Because this analysis shows association rather than direction, both SCRIB-to-partner and partner-to-SCRIB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SCRIB versus ZNF623 in HNSC, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCRIB→partner) and Y-score (partner→SCRIB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZNF623 →	+0.805	+0.376	<.001	<.001	3	10
BRCA	LRRC14 →	+0.630	+0.325	<.001	<.001	3	9
OV	TIGD5 →	+0.707	+0.401	<.001	<.001	3	9
OV	ZNF696 →	+0.686	+0.299	<.001	<.001	3	9
HNSC	ZFAND1 →	+0.771	+0.414	<.001	<.001	3	8
OV	PDE1B →	-0.910	-0.467	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,012 associations by consensus.

SCRIB vs ZNF623 — HNSC

Explore this scatter interactively →