SCRIB

Across TCGA patient cohorts, SCRIB mutation is significantly associated with the RNA expression of many other genes, with 1,350 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCRIB-associated genes across cancer lineages are EI24, SFXN1, and WDR76. Each is linked with SCRIB in more than 3 cancer types. Because this analysis shows association rather than direction, both SCRIB-to-partner and partner-to-SCRIB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EI24 grouped by SCRIB-low versus SCRIB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCRIB→partner) and Y-score (partner→SCRIB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EI24 →	+0.340	+2.628	.009	.005	3	3
UCEC	SFXN1 →	+0.320	+2.160	.007	.002	3	3
UCEC	WDR76 →	+0.546	+1.857	.001	<.001	3	3
STAD	MRPS36 →	+0.606	+3.303	<.001	.007	3	3
STAD	ARHGEF38-IT1 →	+0.902	+3.182	<.001	.009	3	3
BLCA	UQCR10 →	+0.417	+3.244	.008	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,350 associations by consensus.

EI24 by SCRIB expression — UCEC

Explore this box plot interactively →