SCRIB

Across TCGA patient cohorts, SCRIB mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCRIB-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and MEK1. Each is linked with SCRIB in more than 4 cancer types. Because this analysis shows association rather than direction, both SCRIB-to-partner and partner-to-SCRIB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SCRIB-low versus SCRIB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCRIB→partner) and Y-score (partner→SCRIB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.466	+1.874	.019	.049	3	5
UCEC	EGFR_pY1068 →	-0.215	-1.874	.010	.049	3	3
UCEC	MEK1 →	+0.299	+2.000	.014	.009	3	2
UCEC	A-Raf_pS299 →	-0.081	-1.700	.042	.042	3	2
UCEC	ERK2 →	+0.129	+2.584	.046	.010	3	2
UCEC	N-Ras →	-0.105	-2.680	.008	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Caspase-7-cleavedD198 by SCRIB expression — UCEC

Explore this box plot interactively →