SCRIB

Across TCGA cell cohorts, SCRIB RNA expression is significantly associated with the go_rna of many other GO terms, with 3,833 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SCRIB-associated GO terms across cancer lineages are Synaptic vesicle targeting, Cellular response to salt, and P-body assembly. Each is linked with SCRIB in more than 12 cancer types. Because this analysis shows association rather than direction, both SCRIB-to-partner and partner-to-SCRIB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Synaptic vesicle targeting grouped by SCRIB-low versus SCRIB-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCRIB→partner) and Y-score (partner→SCRIB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Synaptic vesicle targeting →	+0.279	+0.980	<.001	<.001	3	13
PANCREAS	Cellular response to salt →	+0.130	+0.815	<.001	.001	3	13
BONE	P-body assembly →	+0.134	+1.321	<.001	<.001	3	12
LUNG_SCLC	Mammary gland duct morphogenesis →	+0.209	+0.636	.001	.001	3	12
BONE	Nucleosome disassembly →	+0.140	+0.937	<.001	<.001	3	12
BONE	Positive regulation of DNA replication →	+0.146	+1.500	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,833 associations by consensus.

Synaptic vesicle targeting by SCRIB expression — BONE

Explore this box plot interactively →