SCRIB

Across TCGA cell cohorts, SCRIB mutation is significantly associated with the RNA expression of many other genes, with 1,112 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCRIB-associated genes across cancer lineages are IFNA13, ASPHD2, and GLTP. Each is linked with SCRIB in more than 1 cancer types. Because this analysis shows association rather than direction, both SCRIB-to-partner and partner-to-SCRIB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA13 grouped by SCRIB-low versus SCRIB-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCRIB→partner) and Y-score (partner→SCRIB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	IFNA13 →	+0.043	+5.169	<.001	.004	3	2
BLOOD_Leukemia	ASPHD2 →	+0.703	+2.252	.001	.003	3	2
BLOOD_Leukemia	GLTP →	+0.556	+3.380	.001	.001	3	2
LARGE_INTESTINE	FAHD2B →	+0.709	+3.584	.007	<.001	3	2
BLOOD_Leukemia	TMEM268 →	+0.674	+2.252	.008	.003	3	2
BLOOD_Leukemia	STK17A →	+0.923	+2.629	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,112 associations by consensus.

IFNA13 by SCRIB expression — BONE

Explore this box plot interactively →