SCPEP1

Across TCGA patient cohorts, SCPEP1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCPEP1-associated genes across cancer lineages are PCNA, EGFR_pY1068, and FoxM1. Each is linked with SCPEP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCPEP1-to-partner and partner-to-SCPEP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SCPEP1-low versus SCPEP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCPEP1→partner) and Y-score (partner→SCPEP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.335	+3.169	.003	.019	3	2
UCEC	EGFR_pY1068 →	-0.322	-3.321	.014	.010	2	2
UCEC	FoxM1 →	+0.358	+3.009	.008	.019	3	1
UCEC	MEK1 →	+0.590	+3.321	.002	.010	3	1
UCEC	Myosin-IIa →	+0.282	+3.177	.005	.010	3	1
UCEC	INPP4B →	-0.470	-3.000	.005	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

PCNA by SCPEP1 expression — UCEC

Explore this box plot interactively →