SCP2D1-AS1

Across TCGA pan-cancer cohorts, SCP2D1-AS1 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated SCP2D1-AS1 data layer compared with 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SCP2D1-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SCP2D1-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and LUAD show a favorable association.

HNSC, THCA, and LUSC are the cancer types where SCP2D1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.121	0.428	<.001	63	view →
THCA	OS	Tertile	IV	0.326	0.892	<.001	51	view →
LUSC	OS	Tertile	II,III,IV	0.250	0.439	.002	36	view →
BRCA	OS	Tertile	All	0.995	0.957	.001	30	view →
STAD	DFS	Quartile	All	0.511	0.749	.001	27	view →
COAD	DFS	Tertile	All	0.521	0.715	.025	18	view →
LUAD	DFS	Tertile	III,IV	1.000	0.620	.021	18	view →
CESC	OS	Tertile	All	0.673	0.813	.023	12	view →
ACC	DFS	Tertile	All	0.195	0.748	.003	9	view →
SKCM	OS	Tertile	IV	0.415	0.861	.014	9	view →
GBM	DFS	Tertile	All	0.426	0.237	.040	9	view →
LIHC	OS	Tertile	All	0.560	0.792	.018	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

SCP2D1-AS1–HNSC (OS)

Open the HNSC breakdown →