SCP2

Across TCGA patient cohorts, SCP2 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCP2-associated genes across cancer lineages are A-Raf_pS299, Rad50, and Caspase-7-cleavedD198. Each is linked with SCP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SCP2-to-partner and partner-to-SCP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by SCP2-low versus SCP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCP2→partner) and Y-score (partner→SCP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.124	-1.906	.001	.015	3	3
UCEC	Rad50 →	-0.178	-1.321	.028	.029	3	3
UCEC	Caspase-7-cleavedD198 →	+0.661	+2.415	<.001	.002	3	3
UCEC	Notch1 →	+0.208	+2.428	<.001	.001	3	2
UCEC	PCNA →	+0.212	+2.584	.003	.001	3	2
UCEC	TFRC →	+0.505	+2.807	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

A-Raf_pS299 by SCP2 expression — UCEC

Explore this box plot interactively →