SCOC

Across TCGA pan-cancer cohorts, SCOC mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SCOC’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where SCOC mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SCOC is over-expressed in tumor, although a few such as CCRCC and HNSC show the opposite, repressed pattern.

CCRCC, HNSC, and COAD are the cancer types where SCOC tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SCOC mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	IV	−0.644	<.001	12	view →
HNSC	Male	All	−0.275	<.001	11	view →
COAD	Male	III,IV	−0.522	<.001	9	view →
LUAD	Male	II,III,IV	+0.409	<.001	9	view →
LSCC	Male	III,IV	−0.256	.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

SCOC–CCRCC

Open the CCRCC breakdown →