SCOC

Across TCGA cell cohorts, SCOC protein abundance is significantly associated with the RNA expression of many other genes, with 4,115 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SCOC-associated genes across cancer lineages are POLR1F, POLD2, and GADD45A. Each is linked with SCOC in more than 9 cancer types. Because this analysis shows association rather than direction, both SCOC-to-partner and partner-to-SCOC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SCOC versus POLR1F in SKIN, with a Pearson correlation of 0.64.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCOC→partner) and Y-score (partner→SCOC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	POLR1F →	+0.957	+0.668	<.001	.001	3	10
LUNG_NSCLC_LUAD	POLD2 →	+0.345	+0.449	.008	.002	3	6
SOFT_TISSUE	GADD45A →	+1.719	+0.798	.004	.008	3	4
SKIN	KLHL7 →	+0.732	+0.605	.003	.001	3	4
SKIN	SLC47A1 →	+1.671	+0.448	<.001	.002	3	4
SKIN	JAZF1 →	+1.374	+0.630	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,115 associations by consensus.

SCOC vs POLR1F — SKIN

Explore this scatter interactively →