SCO2

Across TCGA patient cohorts, SCO2 protein abundance is significantly associated with the RNA expression of many other genes, with 6,311 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SCO2-associated genes across cancer lineages are TTLL12, CHCHD10, and ACO2. Each is linked with SCO2 in more than 4 cancer types. Because this analysis shows association rather than direction, both SCO2-to-partner and partner-to-SCO2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SCO2 versus TTLL12 in HNSC, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCO2→partner) and Y-score (partner→SCO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TTLL12 →	+0.740	+0.271	<.001	<.001	3	5
HNSC	CHCHD10 →	+0.752	+0.246	.001	<.001	3	5
CCRCC	ACO2 →	+0.622	+0.333	<.001	<.001	3	5
OV	TRABD →	+0.741	+0.339	<.001	<.001	3	4
COAD	RBM4B →	-0.334	-0.289	.006	.003	3	4
CCRCC	AMN →	+1.407	+0.254	.002	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,311 associations by consensus.

SCO2 vs TTLL12 — HNSC

Explore this scatter interactively →