SCO1

Across TCGA pan-cancer cohorts, SCO1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SCO1 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SCO1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SCO1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

PDAC, LSCC, and CCRCC are the cancer types where SCO1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	III,IV	0.928	0.465	.011	32	view →
LSCC	OS	Median	II,III,IV	0.890	0.666	.009	12	view →
CCRCC	OS	Quartile	III,IV	1.000	0.484	.002	10	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SCO1–PDAC (DFS)

Open the PDAC breakdown →