SCO1

Across TCGA patient cohorts, SCO1 mutation is significantly associated with the RNA expression of many other genes, with 1,291 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCO1-associated genes across cancer lineages are RNU6-668P, LIN7C, and NOCT. Each is linked with SCO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCO1-to-partner and partner-to-SCO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-668P grouped by SCO1-low versus SCO1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCO1→partner) and Y-score (partner→SCO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-668P →	+0.498	+6.763	<.001	<.001	3	2
UCEC	LIN7C →	+0.666	+3.708	.001	<.001	3	1
UCEC	NOCT →	+0.716	+3.467	<.001	.002	3	1
UCEC	MBIP →	+0.626	+3.330	.009	.005	3	1
UCEC	KCTD14 →	+1.061	+2.839	.001	.001	3	1
UCEC	ACSL1 →	+0.654	+2.818	.007	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,291 associations by consensus.

RNU6-668P by SCO1 expression — HNSC

Explore this box plot interactively →