SCNN1D

Across TCGA pan-cancer cohorts, SCNN1D Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SCNN1D data layer compared with 25 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SCNN1D Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SCNN1D expression acts as an unfavorable survival marker.

HNSC, READ, and LUAD are the cancer types where SCNN1D Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.161	0.688	<.001	45	view →
READ	OS	Median	II,III,IV	0.187	0.644	.023	12	view →
LUAD	OS	Median	All	0.235	0.790	.002	9	view →
GBM	OS	Median	All	0.026	0.416	<.001	6	view →
SARC	OS	Median	All	0.238	0.826	.001	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SCNN1D–HNSC (OS)

Open the HNSC breakdown →