SCNM1

Across TCGA patient cohorts, SCNM1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCNM1-associated genes across cancer lineages are GSK-3_pS9, JNK2, and MIG-6. Each is linked with SCNM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCNM1-to-partner and partner-to-SCNM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3_pS9 grouped by SCNM1-low versus SCNM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCNM1→partner) and Y-score (partner→SCNM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3_pS9 →	-0.642	-2.999	<.001	.035	3	1
UCEC	JNK2 →	+0.228	+3.584	.017	.002	3	1
UCEC	MIG-6 →	+0.118	+2.472	.014	.011	3	1
UCEC	MSH2 →	-0.309	-2.973	.005	.035	3	1
UCEC	mTOR_pS2448 →	-0.204	-2.459	.004	.020	3	1
UCEC	p27_pT157 →	+0.065	+2.820	.019	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

GSK-3_pS9 by SCNM1 expression — UCEC

Explore this box plot interactively →