Across TCGA pan-cancer cohorts, SCN8A mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated SCN8A data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher SCN8A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SCN8A expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

GBM are the cancer types where SCN8A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Quartile	All	1.000	0.806	.018	1	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: SCN8A tumor-vs-normal RNA expression · all SCN8A data types