SCN4B

Across TCGA pan-cancer cohorts, SCN4B mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SCN4B data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SCN4B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SCN4B expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC and GBM are the cancer types where SCN4B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	III,IV	1.000	0.529	.016	9	view →
GBM	OS	Quartile	All	0.308	0.546	.043	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SCN4B–LSCC (DFS)

Open the LSCC breakdown →