SCN1A

Across TCGA patient cohorts, SCN1A protein abundance is significantly associated with the RNA expression of many other genes, with 1,941 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SCN1A-associated genes across cancer lineages are SOX10, NEFH, and MCM5. Each is linked with SCN1A in more than 1 cancer types. Because this analysis shows association rather than direction, both SCN1A-to-partner and partner-to-SCN1A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SCN1A versus SOX10 in GBM, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN1A→partner) and Y-score (partner→SCN1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SOX10 →	+1.235	+0.345	<.001	<.001	3	1
GBM	NEFH →	+1.006	+0.313	<.001	<.001	3	1
GBM	MCM5 →	-0.431	-0.365	.003	.001	3	1
GBM	RASD2 →	+0.387	+0.304	.003	<.001	3	1
GBM	SYNGR1 →	+0.655	+0.287	<.001	<.001	3	1
GBM	PNPLA5 →	+0.214	+0.284	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,941 associations by consensus.

SCN1A vs SOX10 — GBM

Explore this scatter interactively →