SCN1A

Across TCGA patient cohorts, SCN1A mutation is significantly associated with the RNA expression of many other genes, with 7,973 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCN1A-associated genes across cancer lineages are MND1, PLK4, and PGM3. Each is linked with SCN1A in more than 6 cancer types. Because this analysis shows association rather than direction, both SCN1A-to-partner and partner-to-SCN1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MND1 grouped by SCN1A-low versus SCN1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN1A→partner) and Y-score (partner→SCN1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MND1 →	+0.642	+1.612	<.001	<.001	3	7
LUAD	PLK4 →	+0.713	+3.735	<.001	<.001	3	6
UCEC	PGM3 →	+0.371	+1.600	<.001	<.001	3	6
STAD	ZNF367 →	+0.735	+3.207	.001	.009	3	5
STAD	UQCRH →	+0.520	+3.203	<.001	.008	3	5
LUAD	ALYREF →	+0.605	+3.157	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,973 associations by consensus.

MND1 by SCN1A expression — UCEC

Explore this box plot interactively →