SCN1A

Across TCGA cell cohorts, SCN1A RNA expression is significantly associated with the go_rna of many other GO terms, with 501 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SCN1A-associated GO terms across cancer lineages are Gamma-aminobutyric acid signaling pathway, Microtubule-based transport, and Regulation of alternative mRNA splicing, via spliceosome. Each is linked with SCN1A in more than 3 cancer types. Because this analysis shows association rather than direction, both SCN1A-to-partner and partner-to-SCN1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gamma-aminobutyric acid signaling pathway grouped by SCN1A-low versus SCN1A-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN1A→partner) and Y-score (partner→SCN1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Gamma-aminobutyric acid signaling pathway →	-0.152	-0.108	<.001	.003	3	4
LUNG_SCLC	Microtubule-based transport →	+0.059	+1.647	<.001	<.001	3	3
LUNG_SCLC	Regulation of alternative mRNA splicing, via spliceosome →	+0.053	+1.094	.007	.007	3	3
SKIN	Negative regulation of cytosolic calcium ion concentration →	-0.137	-0.100	.004	.006	3	3
LUNG_SCLC	Transport along microtubule →	+0.070	+1.526	.002	<.001	3	3
LUNG_SCLC	Primary miRNA processing →	+0.141	+2.050	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 501 associations by consensus.

Gamma-aminobutyric acid signaling pathway by SCN1A expression — SKIN

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