SCN1A

Across TCGA cell cohorts, SCN1A mutation is significantly associated with the RNA expression of many other genes, with 1,193 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCN1A-associated genes across cancer lineages are WRAP73, MTF2, and TMEM41B. Each is linked with SCN1A in more than 2 cancer types. Because this analysis shows association rather than direction, both SCN1A-to-partner and partner-to-SCN1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WRAP73 grouped by SCN1A-low versus SCN1A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCN1A→partner) and Y-score (partner→SCN1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	WRAP73 →	+0.480	+1.949	.001	.002	3	3
LARGE_INTESTINE	MTF2 →	+0.513	+1.949	.004	.002	3	3
BLOOD_Leukemia	TMEM41B →	+0.551	+3.366	.004	.002	3	3
LARGE_INTESTINE	DTWD2 →	+0.585	+3.321	<.001	.002	3	3
LARGE_INTESTINE	LYSMD3 →	+0.518	+3.321	.005	.002	3	3
LARGE_INTESTINE	TDP1 →	+0.384	+1.949	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,193 associations by consensus.

WRAP73 by SCN1A expression — LARGE_INTESTINE

Explore this box plot interactively →