SCML4

Across TCGA pan-cancer cohorts, SCML4 mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated SCML4 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SCML4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SCML4 expression acts as an unfavorable survival marker.

LSCC are the cancer types where SCML4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	II,III,IV	0.263	0.836	.017	8	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

SCML4–LSCC (OS)

Open the LSCC breakdown →