SCML4

Across TCGA patient cohorts, SCML4 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCML4-associated genes across cancer lineages are MEK1, p53, and Annexin-1. Each is linked with SCML4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCML4-to-partner and partner-to-SCML4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SCML4-low versus SCML4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCML4→partner) and Y-score (partner→SCML4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.528	+3.247	<.001	<.001	3	2
UCEC	p53 →	-0.305	-2.584	.039	.010	3	2
UCEC	Annexin-1 →	+0.737	+3.604	<.001	.001	3	2
UCEC	ATM →	-0.732	-2.807	<.001	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.629	+3.341	.005	.005	3	2
UCEC	14-3-3_beta →	-0.129	-3.673	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

MEK1 by SCML4 expression — UCEC

Explore this box plot interactively →