SCML4

Across TCGA cell cohorts, SCML4 protein abundance is significantly associated with the go_rna of many other GO terms, with 730 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SCML4-associated GO terms across cancer lineages are Positive regulation of neuron apoptotic process, Regulation of release of cytochrome c from mitochondria, and Negative regulation of cholesterol metabolic process. Each is linked with SCML4 in more than 4 cancer types. Because this analysis shows association rather than direction, both SCML4-to-partner and partner-to-SCML4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of neuron apoptotic process grouped by SCML4-low versus SCML4-high in SOFT_TISSUE.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCML4→partner) and Y-score (partner→SCML4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of neuron apoptotic process →	+0.065	+1.872	.008	.004	2	5
CNS	Regulation of release of cytochrome c from mitochondria →	+0.207	+1.426	.002	.002	3	3
LUNG_NSCLC_LUAD	Negative regulation of cholesterol metabolic process →	-0.151	-1.710	.007	.005	3	3
SOFT_TISSUE	Positive regulation of peptidase activity →	+0.292	+1.872	.004	.004	3	3
BLOOD_Leukemia	Embryonic heart tube development →	+0.057	+0.933	.004	.002	3	3
BLOOD_Leukemia	Smooth muscle tissue development →	+0.071	+0.712	.004	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 730 associations by consensus.

Positive regulation of neuron apoptotic process by SCML4 expression — SOFT_TISSUE

Explore this box plot interactively →