SCML4

Across TCGA cell cohorts, SCML4 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCML4-associated genes across cancer lineages are CLDN17, PRAMEF20, and LRRC3C. Each is linked with SCML4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCML4-to-partner and partner-to-SCML4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLDN17 grouped by SCML4-low versus SCML4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCML4→partner) and Y-score (partner→SCML4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CLDN17 →	+0.052	+3.930	.001	.003	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	LRRC3C →	+0.365	+3.777	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR13C4 →	+0.022	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR13C2 →	+0.012	+4.887	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

CLDN17 by SCML4 expression — LARGE_INTESTINE

Explore this box plot interactively →