SCML2P2

Across TCGA pan-cancer cohorts, SCML2P2 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated SCML2P2 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SCML2P2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SCML2P2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LAML show a favorable association.

HNSC, MESO, and LAML are the cancer types where SCML2P2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	II,III,IV	0.650	0.508	.008	40	view →
MESO	DFS	Median	II,III,IV	0.271	0.629	.008	36	view →
LAML	DFS	Median	All	0.539	0.242	<.001	28	view →
COAD	OS	Quartile	All	0.466	0.668	.013	26	view →
LIHC	DFS	Quartile	II,III,IV	0.291	0.496	.002	24	view →
LUAD	OS	Tertile	II,III,IV	0.589	0.355	.009	22	view →
KIRP	OS	Median	All	0.965	0.900	.013	22	view →
ACC	DFS	Tertile	III,IV	0.554	0.082	.001	19	view →
BLCA	DFS	Tertile	All	0.204	0.492	.018	18	view →
READ	OS	Median	II,III,IV	0.779	0.485	.015	14	view →
TGCT	DFS	Tertile	All	0.967	0.711	.001	14	view →
LUSC	DFS	Tertile	III,IV	0.403	0.951	.008	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

SCML2P2–HNSC (DFS)

Open the HNSC breakdown →