SCML2

Across TCGA patient cohorts, SCML2 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCML2-associated genes across cancer lineages are PKC-delta_pS664, Caspase-7-cleavedD198, and Notch1. Each is linked with SCML2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SCML2-to-partner and partner-to-SCML2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-delta_pS664 grouped by SCML2-low versus SCML2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCML2→partner) and Y-score (partner→SCML2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-delta_pS664 →	-0.076	-2.222	.038	.009	3	3
SKCM	Caspase-7-cleavedD198 →	+0.573	+1.510	.011	.032	3	3
UCEC	Notch1 →	+0.129	+1.293	.002	.031	3	2
UCEC	Annexin-1 →	+0.493	+1.460	.002	.013	3	2
UCEC	BRD4 →	+0.179	+1.999	.034	.028	3	2
UCEC	4E-BP1 →	+0.268	+2.222	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

PKC-delta_pS664 by SCML2 expression — UCEC

Explore this box plot interactively →