SCML2

Across TCGA cell cohorts, SCML2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,453 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SCML2-associated GO terms across cancer lineages are DNA strand elongation, DNA-templated DNA replication, and DNA replication initiation. Each is linked with SCML2 in more than 15 cancer types. Because this analysis shows association rather than direction, both SCML2-to-partner and partner-to-SCML2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA strand elongation grouped by SCML2-low versus SCML2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCML2→partner) and Y-score (partner→SCML2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA strand elongation →	+0.179	+1.204	<.001	.001	3	16
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication →	+0.135	+1.236	<.001	.001	3	16
UPPER_AERODIGESTIVE_TRACT	DNA replication initiation →	+0.157	+1.355	<.001	<.001	3	16
BLOOD_Leukemia	Regulation of DNA replication →	+0.061	+1.445	<.001	<.001	3	16
OVARY	IMP biosynthetic process →	+0.174	+1.365	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Positive regulation of DNA repair →	+0.073	+1.162	<.001	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,453 associations by consensus.

DNA strand elongation by SCML2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →