SCML2

Across TCGA cell cohorts, SCML2 mutation is significantly associated with the drug of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCML2-associated genes across cancer lineages are GSK2801, AGI-6780, and Picolinici-acid. Each is linked with SCML2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCML2-to-partner and partner-to-SCML2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK2801 grouped by SCML2-low versus SCML2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCML2→partner) and Y-score (partner→SCML2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GSK2801 →	+0.343	+2.649	.031	.046	3	1
LARGE_INTESTINE	AGI-6780 →	+0.382	+2.646	.049	.047	3	1
LARGE_INTESTINE	Picolinici-acid →	+0.303	+2.646	.038	.047	1	2
LARGE_INTESTINE	AZD5991 →	+1.087	+2.649	.003	.046	2	1
LARGE_INTESTINE	Oxaliplatin →	+0.623	+2.678	.018	.037	2	1
LARGE_INTESTINE	50869 →	+0.513	+2.678	.014	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

GSK2801 by SCML2 expression — LARGE_INTESTINE

Explore this box plot interactively →