SCML1

Across TCGA pan-cancer cohorts, SCML1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SCML1 data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SCML1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SCML1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LSCC, HNSC, and PDAC are the cancer types where SCML1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	0.347	0.792	.009	23	view →
HNSC	OS	Median	All	0.774	0.919	.024	11	view →
PDAC	OS	Median	All	0.332	0.863	.014	8	view →
CCRCC	DFS	Median	III,IV	0.666	0.225	.019	4	view →
GBM	DFS	Quartile	All	0.214	0.501	.028	2	view →
LUAD	OS	Median	III,IV	0.313	0.819	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SCML1–LSCC (OS)

Open the LSCC breakdown →