SCMH1

Across TCGA patient cohorts, SCMH1 mutation is significantly associated with the RNA expression of many other genes, with 2,352 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCMH1-associated genes across cancer lineages are EMC6, HACL1, and ELOA-AS1. Each is linked with SCMH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SCMH1-to-partner and partner-to-SCMH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EMC6 grouped by SCMH1-low versus SCMH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCMH1→partner) and Y-score (partner→SCMH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EMC6 →	+0.521	+2.201	.004	<.001	3	3
UCEC	HACL1 →	+0.486	+2.458	<.001	.001	3	3
SKCM	ELOA-AS1 →	+0.476	+3.826	.005	<.001	3	2
BLCA	FAM25G →	+0.158	+3.613	.006	.001	3	2
UCEC	MYO19 →	+0.481	+3.971	<.001	<.001	3	2
UCEC	ZNHIT3 →	+0.335	+1.606	.008	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,352 associations by consensus.

EMC6 by SCMH1 expression — UCEC

Explore this box plot interactively →