SCMH1

Across TCGA patient cohorts, SCMH1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCMH1-associated genes across cancer lineages are eEF2, Caspase-7-cleavedD198, and c-Jun_pS73. Each is linked with SCMH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCMH1-to-partner and partner-to-SCMH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by SCMH1-low versus SCMH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCMH1→partner) and Y-score (partner→SCMH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.435	+3.459	.001	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.723	+2.087	.001	.005	3	2
UCEC	c-Jun_pS73 →	-0.131	-2.105	.031	.017	3	2
UCEC	Cyclin-E2 →	+0.160	+2.232	.013	.005	3	2
SKCM	DJ-1 →	+0.222	+2.339	.013	.019	3	1
UCEC	EGFR_pY1068 →	-0.276	-2.807	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

eEF2 by SCMH1 expression — UCEC

Explore this box plot interactively →