SCMH1

Across TCGA cell cohorts, SCMH1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCMH1-associated genes across cancer lineages are OR6S1, OR2T2, and TMEM114. Each is linked with SCMH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCMH1-to-partner and partner-to-SCMH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6S1 grouped by SCMH1-low versus SCMH1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCMH1→partner) and Y-score (partner→SCMH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OR6S1 →	+0.063	+5.285	<.001	.003	3	1
STOMACH	OR2T2 →	+0.153	+5.285	<.001	.003	3	1
STOMACH	TMEM114 →	+0.163	+5.285	<.001	.003	3	1
SKIN	BEND2 →	+0.016	+6.022	<.001	.001	3	1
SKIN	GFRAL →	+0.023	+4.977	<.001	.007	3	1
SKIN	CLEC4C →	+0.054	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

OR6S1 by SCMH1 expression — STOMACH

Explore this box plot interactively →