SCLT1

Across TCGA patient cohorts, SCLT1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCLT1-associated genes across cancer lineages are 4E-BP1, C-Raf, and eIF4E. Each is linked with SCLT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SCLT1-to-partner and partner-to-SCLT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by SCLT1-low versus SCLT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCLT1→partner) and Y-score (partner→SCLT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.305	+3.700	<.001	.001	3	3
UCEC	C-Raf →	+0.114	+1.247	.019	.045	3	3
UCEC	eIF4E →	+0.203	+2.137	.004	.001	3	2
UCEC	MEK1 →	+0.298	+2.000	.016	.009	3	2
UCEC	PCNA →	+0.237	+3.000	.001	<.001	3	2
UCEC	Annexin-1 →	+0.687	+2.926	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

4E-BP1 by SCLT1 expression — UCEC

Explore this box plot interactively →