SCLT1

Across TCGA cell cohorts, SCLT1 mutation is significantly associated with the RNA expression of many other genes, with 427 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCLT1-associated genes across cancer lineages are OR4A47, C14orf177, and GSG1L2. Each is linked with SCLT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SCLT1-to-partner and partner-to-SCLT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4A47 grouped by SCLT1-low versus SCLT1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCLT1→partner) and Y-score (partner→SCLT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR4A47 →	+0.013	+4.058	<.001	.009	3	3
SKIN	C14orf177 →	+0.012	+4.437	<.001	.004	3	2
BLOOD_Leukemia	GSG1L2 →	+0.034	+4.384	<.001	.006	3	2
BLOOD_Lymphoma	METTL21C →	+0.036	+5.129	<.001	<.001	3	1
LUNG_NSCLC_LUAD	SMYD1 →	+0.016	+3.977	.003	.005	3	1
LUNG_NSCLC_LUAD	LACRT →	+0.116	+4.681	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 427 associations by consensus.

OR4A47 by SCLT1 expression — BLOOD_Lymphoma

Explore this box plot interactively →