SCIMP

Across TCGA patient cohorts, SCIMP mutation is significantly associated with the RNA expression of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCIMP-associated genes across cancer lineages are ATP2B2-IT1, RNU6-709P, and NUTF2P8. Each is linked with SCIMP in more than 1 cancer types. Because this analysis shows association rather than direction, both SCIMP-to-partner and partner-to-SCIMP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP2B2-IT1 grouped by SCIMP-low versus SCIMP-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCIMP→partner) and Y-score (partner→SCIMP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ATP2B2-IT1 →	+0.074	+7.816	<.001	.008	3	2
HNSC	RNU6-709P →	+0.406	+6.763	<.001	<.001	3	2
HNSC	NUTF2P8 →	+0.132	+5.655	<.001	.004	3	2
BLCA	ALDH7A1P4 →	+0.189	+7.640	<.001	.009	3	2
HNSC	GOLGA6D →	+0.011	+5.069	<.001	.008	3	1
BLCA	RNA5SP138 →	+0.274	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

ATP2B2-IT1 by SCIMP expression — SKCM

Explore this box plot interactively →