SCGN

Across TCGA pan-cancer cohorts, SCGN mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SCGN data layer compared with 20 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SCGN mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SCGN expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and GBM are the cancer types where SCGN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	1.000	0.711	<.001	64	view →
PDAC	OS	Median	II,III,IV	0.943	0.722	.004	24	view →
GBM	OS	Median	All	0.279	0.595	.008	6	view →
LUAD	OS	Median	All	0.814	1.000	.038	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SCGN–CCRCC (OS)

Open the CCRCC breakdown →