SCGN

Across TCGA patient cohorts, SCGN mutation is significantly associated with the RNA expression of many other genes, with 3,081 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCGN-associated genes across cancer lineages are DSN1, AP1S3, and SPC25. Each is linked with SCGN in more than 1 cancer types. Because this analysis shows association rather than direction, both SCGN-to-partner and partner-to-SCGN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DSN1 grouped by SCGN-low versus SCGN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCGN→partner) and Y-score (partner→SCGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DSN1 →	+0.560	+2.423	<.001	.001	3	2
SKCM	AP1S3 →	+0.687	+3.836	<.001	<.001	3	2
UCEC	SPC25 →	+0.574	+1.769	.005	.004	3	2
UCEC	RAD17 →	+0.387	+2.721	.004	.003	3	2
UCEC	CENPH →	+0.644	+2.081	<.001	.001	3	2
UCEC	CC2D1B →	+0.219	+1.954	.009	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,081 associations by consensus.

DSN1 by SCGN expression — UCEC

Explore this box plot interactively →