SCGB3A2

Across TCGA patient cohorts, SCGB3A2 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCGB3A2-associated genes across cancer lineages are RNU6-543P, RN7SKP221, and RNU2-47P. Each is linked with SCGB3A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCGB3A2-to-partner and partner-to-SCGB3A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-543P grouped by SCGB3A2-low versus SCGB3A2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCGB3A2→partner) and Y-score (partner→SCGB3A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-543P →	+0.283	+8.055	<.001	.007	3	1
BRCA	RN7SKP221 →	+0.099	+8.471	<.001	.005	3	1
BRCA	RNU2-47P →	+0.628	+8.055	<.001	.007	3	1
BRCA	RNA5SP100 →	+0.277	+8.055	<.001	.007	3	1
BRCA	RNA5SP222 →	+0.286	+7.731	<.001	.009	3	1
BRCA	TRDD1 →	+1.367	+9.057	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

RNU6-543P by SCGB3A2 expression — BRCA

Explore this box plot interactively →