SCGB3A1

Across TCGA patient cohorts, SCGB3A1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCGB3A1-associated genes across cancer lineages are C7orf77, MIA-RAB4B, and SPANXN2. Each is linked with SCGB3A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCGB3A1-to-partner and partner-to-SCGB3A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C7orf77 grouped by SCGB3A1-low versus SCGB3A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCGB3A1→partner) and Y-score (partner→SCGB3A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C7orf77 →	+0.183	+3.719	<.001	.008	3	1
UCEC	MIA-RAB4B →	+0.159	+3.863	<.001	.008	3	1
UCEC	SPANXN2 →	+0.397	+3.969	<.001	.005	3	1
UCEC	RNU6-444P →	+0.675	+4.148	.008	.004	3	1
UCEC	MIR574 →	+0.649	+4.148	.003	.004	3	1
UCEC	SNORD90 →	+0.606	+3.840	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

C7orf77 by SCGB3A1 expression — UCEC

Explore this box plot interactively →