SCGB2A2

Across TCGA patient cohorts, SCGB2A2 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible SCGB2A2-associated genes across cancer lineages are MIR5197, IGFL3, and MIR1225. Each is linked with SCGB2A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCGB2A2-to-partner and partner-to-SCGB2A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR5197 grouped by SCGB2A2-low versus SCGB2A2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCGB2A2→partner) and Y-score (partner→SCGB2A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR5197 →	+0.264	+7.924	.002	.008	3	2
UCEC	IGFL3 →	+1.129	+3.814	<.001	.005	3	1
UCEC	MIR1225 →	+0.792	+5.027	<.001	<.001	3	1
UCEC	RPS3AP8 →	+0.186	+3.296	<.001	.008	3	1
UCEC	RN7SKP132 →	+0.239	+4.877	<.001	.003	3	1
UCEC	SCARNA21B →	+0.411	+3.561	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

MIR5197 by SCGB2A2 expression — LUSC

Explore this box plot interactively →