SCGB2A2

mutation — cross-omics
Cross-omicsMUTATION → IMMUNEPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SCGB2A2 mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. OV shows the largest number of these associations.

The most reproducible SCGB2A2-associated genes across cancer lineages are CD4+ Tcm and CD4+ Tem. Each is linked with SCGB2A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCGB2A2-to-partner and partner-to-SCGB2A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD4+ Tcm grouped by SCGB2A2-low versus SCGB2A2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCGB2A2→partner) and Y-score (partner→SCGB2A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUSCCD4+ Tcm →+0.014+6.593<.001.02031
OVCD4+ Tem →+0.030+5.930<.001.03231
Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

CD4+ Tcm by SCGB2A2 expression — LUSC

Box plot of CD4+ Tcm in SCGB2A2-low vs SCGB2A2-high samples in LUSC.

Explore this box plot interactively →

Exploration